Big pharma, Partnering

GSK and Clovis in lung cancer pact

Posted on 19 November 2014

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Clovis Oncology have entered into a clinical trial collaboration with GlaxoSmithKline to evaluate a novel combination therapy targeting mutant epidermal growth factor receptor (EGFR) non-small cell lung cancer (NSCLC).

The Phase 1/2 trial of rociletinib given in combination with trametinib is planned to start in 1H 2015.

The trial is designed to assess the safety and activity of the combination in patients with EGFR mutant NSCLC who were previously treated with an EGFR tyrosine kinase inhibitor (TKI).

This clinical trial is designed to test the hypothesis that the combination of two oral drugs targeting different cellular growth pathways, both often active in EGFR mutant NSCLC, will lead to augmented clinical benefit.

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