Proteostasis Therapeutics announced an R&D and commercialization pharma deal with Tokyo-based Astellas Pharma.

The focus of the agreement will be to research and develop compounds that modulate the Unfolded Protein Response (UPR) through the use of Proteostasis’s proprietary “Disease Relevant Translation” and “Proteostasis Network” platform.

The research will focus on a single genetic disease, then spread out to additional conditions that are affected by modulation of the UPR pathway.

A number of genetic diseases, neurodegenerative and retinal degenerative diseases are related to unfolded proteins in the endoplasmic reticulum (ER).

In non-clinical studies, selective modulation of the UPR pathway has improved stressresponse and restored function.

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