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Pharmacyclics forms an pharma alliance with Roche

Posted on 17 October 2014

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Pharmacyclics has entered into a pharma alliance agreement with Roche to evaluate the safety, tolerability and preliminary efficacy of IMBRUVICA (ibrutinib)in combination with GAZYVA (obinutuzumab).Imbruvica is an oral Bruton's tyrosine kinase (BTK) inhibitor.

Gazyva is a new CD20-directed antibody that attacks targeted cells both directly and together with the body's immune system, in patients with non-Hodgkin Lymphoma (NHL) and Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL).

The agreement allows for multiple studies to be considered and conducted.
Initially, a Phase 3 study will be conducted by Pharmacyclics in CLL/SLL.

Plans to evaluate the combination for NHL currently are in development.

Both products are approved and marketed for the treatment of CLL.

The use of these products in combination is investigational only.

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