Big pharma, Biotech, Partnering

Pfizer and Merck & Co. sign biotech partnering pact

Posted on 27 August 2014

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Pfizer and Merck & Co announced a clinical trial biotech partnering deal to test Merck’s Investigational Anti-PD-1 Antibody Pembrolizumab and Pfizer’s Crizotinib (XALKORI) in combination for patients with ALK-positive advanced or metastatic non-small cell lung cancer.

The Phase Ib trial will be initiated.

Pfizer’s XALKORI is a kinase inhibitor indicated for the treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors are anaplastic lymphoma kinase (ALK)-positive as detected by an FDA-approved test.

Merck describes Pembrolizumab (MK-3475) as “an investigational, humanized, monoclonal antibody against PD-1 designed to reactivate anti-tumor immunity.” The company estimates that by the end of 2014, the pembrolizumab development program will include more than 24 clinical trials involving an estimated 6,000 patients in nearly 300 locations worldwide.

For further deal information visit Current Agreements (subscription required)


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