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Vivaldi Biosciences biotech partners with Baxter for influenza vaccine assets

Posted on 11 October 2013

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Vivaldi Biosciences has acquired from Baxter Healthcare research and development assets, including intellectual property, clinical data, know-how and materials, for LAIVs in which the gene for influenza nonstructural protein 1 has been fully deleted.

NS1 is a multifunctional virulence factor of influenza.

In a Phase 1 clinical study of a delta-NS1 LAIV for highly pathogenic avian influenza A(H5N1) (“bird flu”), two Phase 1 studies of delta-NS1 LAIVs for seasonal H1N1 influenza strains, and a Phase 1/2 study of a trivalent delta-NS1 LAIV for seasonal influenza, the candidate vaccines were well-tolerated and generated positive immunogenicity data in a dose-dependent manner.

The vaccines evaluated in the four clinical studies were produced using Vero cell substrate technologies.

The acquired assets complement and substantially broaden Vivaldi’s LAIV platform and product development opportunities in pandemic preparedness and seasonal influenza.

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